Essential Information & explanations, latest texts & monographs on
Albumin.
Albumin
Albumin is a blood plasma protein that is produced in the liver
and forms a large proportion of all plasma protein.
The normal range of albumin concentrations in human blood is 3.5 to 5.0 g/dL, and
albumin normally constitutes about 60% of plasma protein; all other proteins present in blood plasma are referred to collectively as globulin.
Albumin is essential for maintaining the oncotic pressure needed
for proper distribution of body fluids between intravascular compartments
and body tissues.
Because smaller animals, (for example rats,) function at a lower blood pressure, they need less oncotic pressure to balance this, and thus need less albumin to maintain proper fluid distribution.
Functions of albumin:
- Maintains oncotic pressure
- Transports thyroid hormones
- Transports other hormones, particularly fat soluble ones
- Transports unconjugated bilirubin
- Transports many drugs
- Competitively binds calcium ions (Ca++)
- Buffers pH
Causes of albumin deficiency:
- Cirrhosis of the liver (most commonly).
- Decreased production (e.g. starvation).
- Excess excretion by the kidneys (such as in nephrotic syndrome).
- Excess loss in bowel (protein losing enteropathy).
The above article is adapted from from Wikipedia All Wikipedia article text is available under the terms of the GNU Free Documentation License
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from PUBMED
1: Stokes MB, Markowitz GS, Lin J, Valeri AM, D'Agati VD.
Glomerular tip lesion: A distinct entity within the minimal change
disease/focal segmental glomerulosclerosis spectrum.
Kidney Int. 2004 May;65(5):1690-702.
PMID: 15086908
2: Chang PC, Chen TH, Chang CJ, Hou CC, Chan P, Lee HM.
Advanced glycosylation end products induce inducible nitric oxide synthase
(iNOS) expression via a p38 MAPK-dependent pathway.
Kidney Int. 2004 May;65(5):1664-75.
PMID: 15086905
3: Zafiriou S, Stanners SR, Polhill TS, Poronnik P, Pollock CA.
Pioglitazone increases renal tubular cell albumin uptake but limits
proinflammatory and fibrotic responses.
Kidney Int. 2004 May;65(5):1647-53.
PMID: 15086903
4: Santoso JT, Cannada T, O'Farrel B, Alladi K, Coleman RL.
Subjective versus objective nutritional assessment study in women with
gynecological cancer: a prospective cohort trial.
Int J Gynecol Cancer. 2004 Mar-Apr;14(2):220-3.
PMID: 15086719
5: Balakrishnan VS, Guo D, Rao M, Jaber BL, Tighiouart H, Freeman RL, Huang C,
King AJ, Pereira BJ; The HEMO Study Group.
Cytokine gene polymorphisms in hemodialysis patients: Association with
comorbidity, functionality, and serum albumin.
Kidney Int. 2004 Apr;65(4):1449-60.
PMID: 15086488
6: Frankenfield DL, Roman SH, Rocco MV, Bedinger MR, McClellan WM.
Disparity in outcomes for adult Native American hemodialysis patients? Findings
from the ESRD Clinical Performance Measures Project, 1996 to 1999.
Kidney Int. 2004 Apr;65(4):1426-34.
PMID: 15086485
7: Kaysen GA, Dubin JA, Muller HG, Rosales L, Levin NW, Mitch WE; The HEMO
Study Group.
Inflammation and reduced albumin synthesis associated with stable decline in
serum albumin in hemodialysis patients.
Kidney Int. 2004 Apr;65(4):1408-1415.
PMID: 15086482
8: Bardutzky J, Georgiadis D, Kollmar R, Schwarz S, Schwab S.
Energy demand in patients with stroke who are sedated and receiving mechanical
ventilation.
J Neurosurg. 2004 Feb;100(2):266-71.
PMID: 15086234
9: Suzuki A, Zheng YW, Fukao K, Nakauchi H, Taniguchi H.
Liver repopulation by c-Met-positive stem/progenitor cells isolated from the
developing rat liver.
Hepatogastroenterology. 2004 Mar-Apr;51(56):423-6.
PMID: 15086173
10: Ulinski T, Lhopital C, Cloppet H, Feit JP, Bourlon I, Morin D, Cochat P.
Munchausen syndrome by proxy with massive proteinuria and gastrointestinal
hemorrhage.
Pediatr Nephrol. 2004 Apr 15 [Epub ahead of print]
PMID: 15085420
11: Yeh CN, Jan YY, Lee WC, Chen MF.
Hepatic Resection for Hepatocellular Carcinoma with Obstructive Jaundice due to
Biliary Tumor Thrombi.
World J Surg. 2004 Apr 19 [Epub ahead of print]
PMID: 15085398
12: Olsen MH, Wachtell K, Bella JN, Palmieri V, Gerdts E, Smith G, Nieminen MS,
Dahlof B, Ibsen H, Devereux RB.
Albuminuria predicts cardiovascular events independently of left ventricular
mass in hypertension: a LIFE substudy.
J Hum Hypertens. 2004 Apr 15 [Epub ahead of print]
PMID: 15085167
13: McCarthy ET, Sharma M, Sharma R, Falk RJ, Jennette JC.
Sera from patients with collapsing focal segmental glomerulosclerosis increase
albumin permeability of isolated glomeruli.
J Lab Clin Med. 2004 Apr;143(4):225-9.
PMID: 15085081
14: Keiver K, Weinberg J.
Effect of duration of maternal alcohol consumption on calcium metabolism and
bone in the fetal rat.
Alcohol Clin Exp Res. 2004 Mar;28(3):456-67.
PMID: 15084904
15: Hamrahian AH, Oseni TS, Arafah BM.
Measurements of serum free cortisol in critically ill patients.
N Engl J Med. 2004 Apr 15;350(16):1629-38.
PMID: 15084695
16: Silva D, Cortez CM, Louro SR.
Chlorpromazine interactions to sera albumins; A study by the quenching of
fluorescence.
Spectrochim Acta A Mol Biomol Spectrosc. 2004 Apr;60(5):1215-23.
PMID: 15084340
17: Shen Y, Jia RP, Luo HQ, Chen XG, Xue DS, Hu ZD.
Enhanced photoluminescence of morin-bovine serum albumin on porous anodized
aluminum oxide.
Spectrochim Acta A Mol Biomol Spectrosc. 2004 Apr;60(5):1007-11.
PMID: 15084318
18: Laven RA, Livesey CT, May SA.
Relationship between acute phase proteins and hoof horn haemorrhages in
postpartum first-lactation heifers.
Vet Rec. 2004 Mar 27;154(13):389-95.
PMID: 15083972
19: Maduell F, Navarro V, Rius A, Torregrosa E, Sanchez JJ, Saborit ML, Ferrero
JA.
[Improvement of nutritional status in patients with short daily on-line
hemodiafiltration]
Nefrologia. 2004;24(1):60-6. Spanish.
PMID: 15083959
20: Sahin I, Noyan T, Karaman E, Yalcinkaya AS, Metin A, Akpolat T.
Mild renal injury in Behcet's disease.
Ren Fail. 2004 Jan;26(1):55-7.
PMID: 15083923
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