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Ames test

The Ames test is a method in genetics to test the strength of a mutagen, that is, if an agent (for example, a chemical), causes mutations in living organisms. The test is named after its inventor, Bruce Ames. The test works by taking bacteria that already have a single mutation, for example, a strain that cannot produce histidine, an amino acid that is essential for the bacterium to live. These bacteria are then exposed to the agent to be tested, and brought into an environment that is ideal for them to live and procreate, except it does not contain histidine. The more mutations the agent caused in the bacteria, the more likely it is for some of them to reverse the original mutation, that is, that the mutation occurs exactly in the right place to allow the bacteria to produce histidine again by themselves. The number of surviving bacteria colonies thus corresponds with the strength of the mutagen.

The above article is adapted from from Wikipedia All Wikipedia article text is available under the terms of the GNU Free Documentation License



Writing: The Political Test (Post-Contemporary Interventions) by Claude Lefort

Adolescent Rorschach Responses: Developmental Trends from Ten to Sixteen Years by Louise Bates Ames

Rorschach Responses in Old Age (The Master Work Series) by Louise Bates Ames

Adolescent Rorschach Responses: Developmental Trends from Ten to Sixteen Years (The Master Work) by Louise Bates Ames

AME Regulations Written Test Book by Michael J. Culhane

Rorschach Responses in Old Age by Louise Bates Ames

Child Rorschach Responses: Developmental Trends from Two to Ten Years by Louise Bates Ames

Child Rorschach Responses: Developmental Trends from Two to Ten Years (The Master Work Series) by Louise Bates Ames

Tests Governing Changing Ame by Macmanus

Phase 4 static tests of the J-97 powered, external augmentor V/STOL model at the NASA, Ames Research Center, November 1983 (SuDoc NAS 1.26:177395) by D. B. Garland

Writing: The Political Test by Claude Lefort

Memoirs of an Aeronautical Engineer: Flight Tests at Ames Research Center: 1940-1970 by Seth B. Anderson

Digital electronic engine control (DEEC) flight evaluation in an F-15 airplane proceedings of a minisymposium held at NASA Ames Research Center, Dryden Flight Research Facility, Edwards, California, May 25-26, 1983 (SuDoc NAS 1.55:2298 by NASA

Toward comparing experiment and theory for corroborative research on hingeless rotor stability in forward flight final technical report under NASA-Ames cooperative agreement by G. Gaonkar

Hybrid laminar flow control experiments in the NASA - Ames, 11-foot tunnel final report (SuDoc NAS 1.26:199360) by W. S. Saric





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Recent Ames_test related patents

From USPTO:




from PUBMED
1:  Zhou L, Haorah J, Chen SC, Wang X, Kolar C, Lawson TA, Mirvish SS. 
 Nitrosation of glycine ethyl ester and ethyl diazoacetate to give the
alkylating agent and mutagen ethyl chloro(hydroximino)acetate.
Chem Res Toxicol. 2004 Mar;17(3):416-23. 
PMID: 15025513 

2:  Zhang FQ, Cao HX. 
 [Biocompatibility of JJ magnetic retainer metal materials]
Shanghai Kou Qiang Yi Xue. 2001 Jun;10(2):116-8. Chinese. 
PMID: 14994033 [PubMed]

3:  Taylor JL, Demyttenaere JC, Abbaspour Tehrani K, Olave CA, Regniers L,
Verschaeve L, Maes A, Elgorashi EE, van Staden J, de Kimpe N. 
 Genotoxicity of melanoidin fractions derived from a standard glucose/glycine
model.
J Agric Food Chem. 2004 Jan 28;52(2):318-23. 
PMID: 14733515 

4:  Yamada K, Suzuki T, Hakura A, Mizutani T, Saeki K. 
 Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450
1A2 in human liver microsomes.
Mutat Res. 2004 Feb 14;557(2):159-65. 
PMID: 14729370 

5:  Zhao HW, Yin XJ, Frazer D, Barger MW, Siegel PD, Millecchia L, Zhong BZ,
Tomblyn S, Stone S, Ma JK, Castranova V, Ma JY. 
 Effects of paving asphalt fume exposure on genotoxic and mutagenic activities
in the rat lung.
Mutat Res. 2004 Feb 14;557(2):137-49. 
PMID: 14729368 

6:  Chen YY, Liu JF, Chen CM, Chao PY, Chang TJ. 
 A study of the antioxidative and antimutagenic effects of Houttuynia cordata
Thunb. using an oxidized frying oil-fed model.
J Nutr Sci Vitaminol (Tokyo). 2003 Oct;49(5):327-33. 
PMID: 14703307 

7:  Park KY, Jung GO, Lee KT, Choi J, Choi MY, Kim GT, Jung HJ, Park HJ. 
 Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua.
J Ethnopharmacol. 2004 Jan;90(1):73-9. 
PMID: 14698512 

8:  Chan Y, Lai CH, Yang HW, Lin YY, Chan CH. 
 The evaluation of Chinese herbal medicine effectiveness on periodontal
pathogens.
Am J Chin Med. 2003;31(5):751-61. 
PMID: 14696678 

9:  Cemeli E, Carder J, Anderson D, Guillamet E, Morillas MJ, Creus A, Marcos R.

 Antigenotoxic properties of selenium compounds on potassium dichromate and
hydrogen peroxide.
Teratog Carcinog Mutagen. 2003;Suppl 2:53-67. 
PMID: 14691980 

10:  Harrington DJ, Cemeli E, Carder J, Fearnley J, Estdale S, Perry PJ, Jenkins
TC, Anderson D. 
 Genotoxicity studies on DNA-interactive telomerase inhibitors with application
as anti-cancer agents.
Teratog Carcinog Mutagen. 2003;Suppl 2:31-41. 
PMID: 14691978 

11:  Hearn MJ, Cynamon MH. 
 Design and synthesis of antituberculars: preparation and evaluation against
Mycobacterium tuberculosis of an isoniazid Schiff base.
J Antimicrob Chemother. 2004 Feb;53(2):185-91. Epub 2003 Dec 19. 
PMID: 14688045 

12:  Nishibayashi H, Kanayama S, Kiyohara T, Yamamoto K, Miyazaki Y, Yasunaga Y,
Shinomura Y, Takeshita T, Takeuchi T, Morimoto K, Matsuzawa Y. 
 Helicobacter pylori-induced enlarged-fold gastritis is associated with
increased mutagenicity of gastric juice, increased oxidative DNA damage, and an
increased risk of gastric carcinoma.
J Gastroenterol Hepatol. 2003 Dec;18(12):1384-91. 
PMID: 14675267 

13:  Catterall F, Kassimi AI, Clifford MN, Ioannides C. 
 Influence of milk on the antimutagenic potential of green and black teas.
Anticancer Res. 2003 Sep-Oct;23(5A):3863-7. 
PMID: 14666689 

14:  Peters U, DeMarini DM, Sinha R, Brooks LR, Warren SH, Chatterjee N, Rothman
N. 
 Urinary mutagenicity and colorectal adenoma risk.
Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1253-6. 
PMID: 14652290 

15:  Nohynek GJ, Kirkland D, Marzin D, Toutain H, Leclerc-Ribaud C, Jinnai H. 
 An assessment of the genotoxicity and human health risk of topical use of kojic
acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one].
Food Chem Toxicol. 2004 Jan;42(1):93-105. 
PMID: 14630133 

16:  Verschaeve L, Kestens V, Taylor JL, Elgorashi EE, Maes A, Van Puyvelde L,
De Kimpe N, Van Staden J. 
 Investigation of the antimutagenic effects of selected South African medicinal
plant extracts.
Toxicol In Vitro. 2004 Feb;18(1):29-35. 
PMID: 14630059 

17:  Miyazawa M, Hisama M. 
 Antimutagenic activity of flavonoids from Chrysanthemum morifolium.
Biosci Biotechnol Biochem. 2003 Oct;67(10):2091-9. 
PMID: 14586095 

18:  Anisimov VN. 
 Effects of exogenous melatonin--a review.
Toxicol Pathol. 2003 Nov-Dec;31(6):589-603. 
PMID: 14585727 

19:  O'Hagan S, Menzel A. 
 A subchronic 90-day oral rat toxicity study and in vitro genotoxicity studies
with a conjugated linoleic acid product.
Food Chem Toxicol. 2003 Dec;41(12):1749-60. 
PMID: 14563400 

20:  Miyazawa M, Hisama M. 
 Antimutagenic activity of phenylpropanoids from clove (Syzygium aromaticum).
J Agric Food Chem. 2003 Oct 22;51(22):6413-22. 
PMID: 14558756 

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Note again ... some material here is adapted from from Wikipedia All Wikipedia article text is available under the terms of the GNU Free Documentation License

©2004, All applicable rights reserved as appropriate.