Essential Information & explanations, latest texts & monographs on
Biochemistry.
Biochemistry
Biochemistry is the study of the chemical reactions and interactions that take place in living organisms. It focuses on the structure and function of cellular components, such as proteins, carbohydrates, lipids, nucleic acids, and other biomolecules.
Presently, biochemistry often focuses on the chemistry of enzyme-mediated reactions, and on the properties of proteins.
For historical reasons, the biochemistry of metabolism has been one of the most extensively described aspect of the cell. Important modern-day areas include the genetic code (DNA, RNA), protein synthesis, cell membrane transport, signal transduction and energy decomposition cycles.
Development of biochemistry
The dawn of biochemistry may have been the discovery of the first enzyme, diastase, in 1833 by Anselme Payen. In 1828, Friedrich Wöhler published a paper about the synthesis of urea, proving that organic compounds can be created artificially, in contrast to the common belief of the time that organic compounds can only be made by living organisms. Since then, biochemistry has advanced, especially since the mid-20th century, with the development of new techniques such as chromatography, X-ray diffraction, NMR, radioisotopic labelling, electron microscopy and molecular dynamics simulations. These techniques allowed for the discovery and detailed analysis of many molecules and metabolic pathways of the cell, such as glycolysis and the Krebs cycle.
Today, the findings of biochemistry are used in many areas, from genetics to molecular biology and from agriculture to medicine. The first application of biochemistry was probably the making of bread using yeast, about 5000 years ago.
Categories
Biochemistry is principally concerned with the chemistry of substances that can be classified into a few major categories:
See also:
General subfields within biology
Anatomy | Botany | Ecology | Evolutionary biology | Genetics | Marine biology | Human biology | Cell biology | Microbiology | Molecular biology | Biochemistry | Origin of life | Paleontology | Physiology | Taxonomy | Xenobiology | Zoology | Bioinformatics
Chemistry
Analytical chemistry |
Organic chemistry |
Inorganic chemistry |
Biochemistry |
Physical chemistry
Periodic table
The above article is adapted from from Wikipedia All Wikipedia article text is available under the terms of the GNU Free Documentation License
Good Carbs, Bad Carbs: An Indispensable Guide to Eating the Right Carbs for Losing Weight and Optimum Health by Johanna Burani
DARWINS BLACK BOX: THE BIOCHEMICAL CHALLENGE TO EVOLUTION by Michael J. Behe
Lippincott's Illustrated Reviews: Biochemistry by Pamela C. Champe
Lehninger Principles of Biochemistry, Third Edition by David L. Nelson
Biochemistry: Board Review Series by Dawn B. Marks
The Demon in the Freezer by Richard Preston
Biochemistry, Chapters 29-34 by Donald Voet
Controlling Cholesterol for Dummies by Carol Ann Rinzler
Molecular Cloning: A Laboratory Manual (3-Volume Set) by Joseph Sambrook
The Demon in the Freezer : A True Story by RICHARD PRESTON
Biological Sequence Analysis : Probabilistic Models of Proteins and Nucleic Acids by Richard Durbin
Name Reactions: A Collection of Detailed Reaction Mechanisms by Jie Jack Li
High-Yield Biochemistry by R. Bruce Wilcox
Serotonin by Syd Baumel
Biochemistry (Chapters 1-34) by John L. Tymoczko
Bibliographic Resources
Updates and comments at Essential Facts blog
Are you interested in Feng Shui?
Price Theory Resources
Fructose, Sucrose, Glucose Core Bibliography
World Class Photographers
Some philosophical movements
Top PDF and eBook Downloads
Recent Biochemistry related patents
From USPTO:
6721663: Method for manipulating protein or DNA sequence data in order to generate complementary peptide ligands
6721583: Method for non-invasive identification of individuals at risk for diabetes
6720488: Transgenic maize seed and method for controlling insect pests
6720480: Maize proteinase inhibitor-like polynucleotides and defense-activated promoter, transformed plants, and methods of use
6720478: RAD51-like polynucleotide and uses thereof
6720477: Signal transduction stress-related proteins and methods of use in plants
6720473: Intra-vascular administration of particles to induce pulmonary hypertension, pulmonary hypertension syndrome, and ascites in poultry
6720472: HMGI proteins in cancer and obesity
6720425: Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
6720415: Compositions and methods for regulating bacterial pathogenesis
6720411: Nanoparticles having oligonucleotides attached thereto and uses therefor
6720410: Nucleic acids encoding enamel matrix related polypeptides
6720408: MDA-7 nucleic acid molecules and pharmaceutical compositions thereof
6720355: Sodium dodecyl sulfate compositions for inactivating prions
6720354: Prevention of neutrophil recruitment
6720347: Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
6720346: Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation
6720340: Nicotine receptor agonists in stem cell and progenitor cell recruitment
6720336: 4,4-biarylpiperidine derivatives
6720335: Sulfonamide inhibitors of aspartyl protease
6720323: Colchinol derivatives as angiogenesis inhibitors
6720317: Inhibitors of factor Xa
6720305: Injectable formulations containing ramoplanin
6720190: Methods for screening compound libraries
6720189: Bilirubin tests as risk predictors for cancer mortality, rheumatoid arthritis, Gilbert's syndrome and all-cause mortality
6720188: Methods and kits for the detection of arginine compounds
6720184: Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination
6720182: Alternative splice variants of CD40
6720177: Porous semiconductor-based optical interferometric sensor
6720174: Phytases
6720172: Genes encoding sulfate assimilation proteins
6720167: Insecticidal bacteria, and methods for making and using them
6720166: Non-a, non-b, non-c, non-c, non-d, non-e hepatitis reagents and methods for their use
6720165: Methods for making antibody fragments and compositions resulting therefrom
6720164: Method of determining substrate, and biosensor
6720162: Assay for kinases and phosphatases
6720159: 88KDA tumorigenic growth factor and antagonists
6720156: Superficial zone protein-binding molecules and uses thereof
6720154: Purified stat proteins and methods of purifying thereof
6720152: Diagnosis of histoplasmosis using antigens specific for H. capsulatum
6720151: Therapeutic agents that inhibit the tup1 pathway
6720149: Methods for concurrently processing multiple biological chip assays
6720147: Nanoparticles having oligonucleotides attached thereto and uses therefor
6720146: Compositions and methods for the therapy and diagnosis of ovarian cancer
6720140: Recombinational cloning using engineered recombination sites
6720139: Genes identified as required for proliferation in Escherichia coli
6720136: Solid phase quenching systems
6720017: Method for reducing the rate of deterioration of perishable horticultural produce
6720014: Phytase-containing foodstuffs and methods of making and using them
from PUBMED
1: Fang J, Kato C, Sato T, Chan O, McKay D.
Biosynthesis and dietary uptake of polyunsaturated fatty acids by piezophilic
bacteria.
Comp Biochem Physiol B Biochem Mol Biol. 2004 Apr;137(4):455-61.
PMID: 15081997
2: Bittman R.
The 2003 ASBMB-Avanti Award in Lipids Address: applications of novel synthetic
lipids to biological problems.
Chem Phys Lipids. 2004 May;129(2):111-31.
PMID: 15081855
3: Hein LK, Bawden M, Muller VJ, Sillence D, Hopwood JJ, Brooks DA.
alpha-l-Iduronidase Premature Stop Codons and Potential Read-Through in
Mucopolysaccharidosis Type I Patients.
J Mol Biol. 2004 Apr 30;338(3):453-62.
PMID: 15081804
4: Ceron JJ, Martinez-Subiela S, Hennemann C, Tecles F.
The effects of different anticoagulants on routine canine plasma biochemistry.
Vet J. 2004 May;167(3):294-301.
PMID: 15080879
5: Zhu BL, Oritani S, Quan L, Li DR, Ogawa M, Maeda H.
[Two suicide fatalities from sodium cyanide ingestion: differences in blood
biochemistry]
Chudoku Kenkyu. 2004 Jan;17(1):65-8. Japanese.
PMID: 15079925
6: Kaneko S, Ichinose H, Fujimoto Z, Kuno A, Yura K, Go M, Mizuno H, Kusakabe
I, Kobayashi H.
Structure and function of a family 10 beta-xylanase chimera of streptomyces
olivaceoviridis E-86 FXYN and cellulomonas fimi Cex.
J Biol Chem. 2004 Apr 12 [Epub ahead of print]
PMID: 15078885
7: Guse AH.
Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose
(cADPR).
Curr Med Chem. 2004 Apr;11(7):847-55.
PMID: 15078169
8: Guillen Schlippe YV, Riera TV, Seyedsayamdost MR, Hedstrom L.
Substitution of the Conserved Arg-Tyr Dyad Selectively Disrupts the Hydrolysis
Phase of the IMP Dehydrogenase Reaction.
Biochemistry. 2004 Apr 20;43(15):4511-21.
PMID: 15078097
9: Kuwata K, Kamatari YO, Akasaka K, James TL.
Slow Conformational Dynamics in the Hamster Prion Protein.
Biochemistry. 2004 Apr 20;43(15):4439-4446.
PMID: 15078089
10: Socha J, Ryzko J, Pawlowska J.
The past and present of the Polish paediatric gastroenterology, hepatology and
nutrition.
J Physiol Pharmacol. 2003 Dec;54 Suppl 3:225-44.
PMID: 15075476
11: Konturek PC, Konturek SJ.
The history of gastrointestinal hormones and the Polish contribution to
elucidation of their biology and relation to nervous system.
J Physiol Pharmacol. 2003 Dec;54 Suppl 3:83-98.
PMID: 15075466
12: Karachalios GN, Karachaliou IG, Bablekos G, Charalabopoulos K.
Fever of unknown origin in carcinoma of the colon.
Med Princ Pract. 2004 May-Jun;13(3):169-70.
PMID: 15073431
13: Biswas G, Barbhuiya JN, Biswas MC, Islam MN, Dutta S.
Clinical pattern of ocular manifestations in vitiligo.
J Indian Med Assoc. 2003 Aug;101(8):478-80.
PMID: 15071800
14: Otterstedt K, Larsson C, Bill RM, Stahlberg A, Boles E, Hohmann S,
Gustafsson L.
Switching the mode of metabolism in the yeast Saccharomyces cerevisiae.
EMBO Rep. 2004 Apr 8 [Epub ahead of print]
PMID: 15071495
15: Sleat DE, Wiseman JA, El-Banna M, Price SM, Verot L, Shen MM, Tint GS,
Vanier MT, Walkley SU, Lobel P.
Genetic evidence for nonredundant functional cooperativity between NPC1 and
NPC2 in lipid transport.
Proc Natl Acad Sci U S A. 2004 Apr 7 [Epub ahead of print]
PMID: 15071184
16: Yaqoob P.
Fatty acids and the immune system: from basic science to clinical applications.
Proc Nutr Soc. 2004 Feb;63(1):89-104.
PMID: 15070442
17: Vincent JB.
Recent advances in the nutritional biochemistry of trivalent chromium.
Proc Nutr Soc. 2004 Feb;63(1):41-7.
PMID: 15070438
18: Sanchez C, Lopez-Barea F, Sanchez-Cabezudo J, Bajo A, Mate A, Martinez E,
Selgas R.
Low vs standard calcium dialysate in peritoneal dialysis: differences in
treatment, biochemistry and bone histomorphometry. A randomized multicentre
study.
Nephrol Dial Transplant. 2004 Apr 6 [Epub ahead of print]
PMID: 15069173
19: Hasan RK, Wulfkuhle JD, Liotta LA, Petricoin EF.
STUDENTJAMA. Molecular technologies for personalized cancer management.
JAMA. 2004 Apr 7;291(13):1644-5.
PMID: 15069056
20: Cundy T, Wheadon L, King A.
Treatment of idiopathic hyperphosphatasia with intensive bisphosphonate
therapy.
J Bone Miner Res. 2004 May;19(5):703-11.
PMID: 15068492
|